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Publications


Nikolay P Kandul, Junru Liu, Anna Buchman, Valentino M Gantz, Ethan Bier, Omar S Akbari
Assessment of a split homing based gene drive for efficient knockout of multiple genes
BiorXiv, July 18th, 2019.
doi: ​doi.org/10.1101/706929

Victor Lopez del Amo, Alena L Bishop, Hector M Sanchez C., Jared B Bennett, Xuechun Feng, John M Marshall,  Ethan Bier,  Valentino M Gantz
Split-gene drive system provides flexible application for safe laboratory investigation and potential field deployment​
BiorXiv, June 28th, 2019.
doi: ​doi.org/10.1101/684597
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Víctor López Del Amo, Brittany S. Leger, Kurt J. Cox, Shubhroz Gill, Alena L. Bishop, Garrett D. Scanlon, James A. Walker, Valentino M. Gantz, Amit Choudhary
Small-molecule control of super-Mendelian inheritance in gene drives​
BiorXiv, June 14th, 2019.
doi: ​doi.org/10.1101/665620
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Annabel Guichard , Tisha Haque , Marketta Bobik , Xiang-Ru S. Xu, Carissa Klanseck , Raja Babu Singh Kushwah, Mateus Berni, Bhagyashree Kaduskar, Valentino M. Gantz & Ethan Bier.
Efficient allelic-drive in Drosophila​
Nature Communications, April 9th, 2019.
PubMed PMID: ​30967548
doi: ​doi.org/10.1038/s41467-019-09694-w
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Hannah A. Grunwald,  Valentino M. Gantz,  Gunnar Poplawski, Xiang-ru S. Xu,  Ethan Bier,  Kimberly L. Cooper
Super-Mendelian inheritance mediated by CRISPR/Cas9 in the female mouse germline.
Nature, January 23rd, 2019.
PubMed PMID: ​​30675057
doi: ​doi.org/10.1038/s41586-019-0875-2

​BioRxiv, July 4th, 2018. 
doi: ​
doi.org/10.1101/362558
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Valentino M. Gantz and Omar S. Akbari.
Gene editing technologies and applications for insects
Current Opinion in Insect Science 2018, 28:xx–yy
​PubMed PMID: 30551769
doi: ​doi.org/10.1016/j.cois.2018.05.006
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Xiang-Ru S. Xu, Valentino M. Gantz, Natalia Siomava, Ethan Bier​.
CRISPR/Cas9 and Active Genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity.
eLife 2017;6:e30281
PubMed PMID: 29274230
doi: 10.7554/eLife.30281
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Zach Adelman, Omar Akbari, John Bauer, Ethan Bier, Cinnamon Bloss, Sarah R Carter, Craig Callender, Adriana Costero-Saint Denis, Peter Cowhey, Brinda Dass, Jason Delborne, Mary Devereaux, Peter Ellsworth, Robert M Friedman, Valentino Gantz, Clark Gibson, Bruce A Hay, Mark Hoddle, Anthony A James, Stephanie James, Lyric Jorgenson, Michael Kalichman, John Marshall, William McGinnis, Jack Newman, Alan Pearson, Hector Quemada, Larisa Rudenko, Anthony Shelton, Joseph M Vinetz, Jennifer Weisman, Brenda Wong & Chris  Wozniak.
Rules of the road for insect gene drive research and testing.
Nature Biotechnology 2017, 35, 716–718
PubMed PMID: 28787415
doi:10.1038/nbt.3926

Gantz VM, Bier E.
The dawn of active genetics.
Bioessays. 2016 Jan; 38(1):50-63. Epub 2015 Dec 10.

PubMed PMID: 26660392
doi: 10.1002/bies.201500102
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​Gantz VM, Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA.
Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi.
PNAS. 2015 Dec 8;112(49):E6736-43. Epub 2015 Nov 23. 
PubMed PMID: 26598698;
​PubMed Central PMCID: PMC4679060
doi: 10.1073/pnas.1521077112. 
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Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J.
BIOSAFETY. Safeguarding gene drive experiments in the laboratory.
Science. 2015 Aug 28;349(6251):927-9.  Epub 2015 Jul 30.
​PubMed PMID: 26229113
​PubMed Central PMCID: PMC4692367
​doi: 10.1126/science.aac7932.
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Valentino M. Gantz & Ethan Bier
The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations
​Science, 24 Apr 2015, Vol. 348, Issue 6233,pp. 442-444. Epub 19 Mar 2015

PMID: 25908821
PMCID: PMC4687737
DOI: 10.1126/science.aaa5945
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